Rabbit polyclonal antibody to COUP~TFI

Chicken ovalbumin upstream promoter transcription factor (COUP~TF) belongs to the NR2 subfamily of the nuclear hormone receptor family. COUP~TFI and COUP~TFII are two of the well~characterized members in the NR2 subfamily. These two members are highly conserved in their two zinc~finger DNA binding domains (DBD) and the ligand binding domain (LBD), and function as repressors or activators of downstream target genes to regulate different biological processes. COUP~TFI and II bind to 5'~AGGTCA~3' motif palindromes, either directly or indirectly, through heterodimer formation with other proteins (e.g. RXRs) to regulate downstream target gene expression. COUP~TFI is involved in neuronal development, tissue patterning, and differentiation. COUP~TFII has been shown to be involved in angiogenesis, glucose homeostasis, and mesenchymal cell commitment.