Rabbit polyclonal antibody to TR4

Testicular receptor 4 (TR4), also called TAK1 or NR2C2, is an orphan receptor in a distinct subclass of the steroid hormone nuclear receptor superfamily along with TR2. TR4 forms heterodimers with TR2 and binds to DNA elements containing direct repeats (DRs). TR4 plays a role in various processes, including neurogenesis, spermatogenesis, RNA metabolism, and protein translation. TR4 can interact with other hormone receptors such as AR and ER to influence protein~protein binding and target gene inactivation. High expression of TR4 correlates with prostate cancer metastasis and invasion through downstream targets such as CCL2 and Ezh2. Expression of TR4 in other cancers such as NSCLC and testicular germ cell tumors has also been associated with poor prognosis.