Rabbit polyclonal antibody to PER2

Biological timepieces called circadian Clocks are responsible for the regulationof hormonal rhythms, sleep cycles and other behaviors. The superchiasmaticnucleus (SCN), which is located in the brain, was the first mammalian circadian Clock to be discovered. A number of transcription factors appearing to bemolecular components of the SCN Clock have been identified. Mutations within the Clock gene increase the length of the endogenous period and cause aloss of rhythmicity of circadian oscillations. Three mammalian period proteins, designated Per1, Per2 and Per3, exhibit circadian rhythyms in the SCN. Duringsubjective night, Per1 and Per2 RNA levels increase in response to light pulses while Per3 RNA levels show no change in response to light pulses. Tim, fortimeless, interacts with Per1 as well as Per2; and Tim and Per1 negativelyregulate Clock~BMAL1~induced transcription.