Rabbit polyclonal antibody to Survivin(Ab~117)

Survivin is a 16 kDa anti~apoptotic protein highly expressed during fetal development and cancer cell malignancy. Survivin binds and inhibits caspase~3, controlling the checkpoint in the G2/M~phase of the cell cycle by inhibiting apoptosis and promoting cell division. This regulatory process requires the phosphorylation of survivin at Thr34 by p34 cdc2 kinase. Gene targeting using a Thr34 phosphorylation~defective survivin mutant, as well as antisense survivin, have been shown to inhibit tumor growth.