Rabbit polyclonal antibody to GSK3β(Ab~9)

Glycogen synthase kinase~3 (GSK~3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK~3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK~3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt~mediated phosphorylation at Ser21 of GSK~3α and Ser9 of GSK~3β. GSK~3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK~3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.