Rabbit polyclonal antibody to Cleaved~ADAM12 (E208)

ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane~anchored, glycosylated, Zn2+ dependent proteases that are involved in cell~cell, cell~matrix interface related processes including fertilization, muscle fusion, secretion of TNF (tumor necrosis factor~α), and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal~domain, a pro~domain, a metalloprotease domain, a disintegrin domain (Integrin ligand), a cysteine~rich region, an epidermal growth factorlike domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAM12 (Meltrin~α) is produced as 2 differentially spliced isoforms, a 718 amino acid secreted form (ADAM12S) and a 881 amino acid membrane~bound form (ADAM12L), and is involved in egg~sperm fusion.