Rabbit polyclonal antibody to Cathepsin H HC (N292)

Cathepsin H (also designated N~benzoylarginine~β~naphthylamide hydrolase, aleurain, cathepsin B3 or cathepsin BA) is a lysosomal cysteine proteinase that mediates degradation of lysosomal proteins. Cathepsin H is a disulfidelinked heavy and light chain dimer produced from a single precursor protein. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Elevated levels of cathepsin H correlates with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene. Full~length and truncated cathepsin H [12 amino acid deletion in the signal peptide region (CTSH∆10~21)] are expressed in prostate tissues, LNCaP, PC~3 and DU~145 prostate cancer cell lines. Cathepsin H mediates maturation of the biologically active surfactant protein~B (SP~B) peptide.