Rabbit polyclonal antibody to ACOT12 (R315)

Abstract Acetyl~CoA plays a fundamental role in cell signaling and metabolic pathways, with its cellular levels tightly controlled through reciprocal regulation of enzymes that mediate its synthesis and catabolism. ACOT12, the primary acetyl~CoA thioesterase in the liver of human, mouse, and rat, is responsible for cleavage of the thioester bond within acetyl~CoA, producing acetate and coenzyme A for a range of cellular processes. The enzyme is regulated by ADP and ATP, which is believed to be mediated through the ligand~induced oligomerization of the thioesterase domains, whereby ATP induces active dimers and tetramers, whereas apo~ and ADP~bound ACOT12 are monomeric and inactive.