Rabbit polyclonal antibody to Bcl~7a (N62)

Bcl~7a (B~cell CLL/lymphoma 7 protein family member A) is a 210 amino acid protein that belongs to the Bcl~7 family. Chromosomal aberrations involving a disruption of the amino~terminus of Bcl~7a may be a cause of B~cell nonHodgkin lymphoma (BNHL). Bcl~7b and Bcl~7c proteins share 90% identity with the N~terminal 51 amino acids of Bcl~7a, suggesting that the three genes are members of an evolutionarily conserved gene family. Bcl~7 gene family may be involved in early development. The Bcl~7a protein interacts with a novel human Polycomb ring finger gene and exists as two alternatively spliced isoforms. Bcl~7a may play a role in GC reaction and/or B~cell lymphomagenesis. The Bcl~7a gene maps to human chromosome 12q24.31. Chromosome 12 encodes over 1,100 genes and comprises approximately 4.5% of the human genome.