Rabbit polyclonal antibody to NFkB p100

NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF~kappa~B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome~mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa~B consensus sequence 5'~GGRNNYYCC~3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF~kappa~B protein complex, which stimulates the HIV enhancer in synergy with p65.