Rabbit polyclonal antibody to EIF3H

Component of the eukaryotic translation initiation factor 3 (eIF~3 complex, which is required for several steps in the initiation of protein synthesis. The eIF~3 complex associates with the 40S ribosome and facilitates the recruitment of eIF~1, eIF~1A, eIF~2:GTP:methionyl~tRNAi and eIF~5 to form the 43S pre~initiation complex (43S PIC. The eIF~3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF~3 complex is also required for disassembly and recycling of post~termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF~3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem~loop binding to exert either translational activation or repression.