Rabbit polyclonal antibody to ATG4A

Autophagy, a process that results in the lysosomal~dependent degradation of cytosolic compartments, is carried out by the autophagosome, which is a double~membrane vesicle whose formation is catalyzed by several autophagy~related gene (Atg) proteins. Atg4a (ATG4 autophagy related 4 homolog A), also known as APG4A or AUTL2, is a 398 amino acid protein that localizes to the cytoplasm and belongs to the peptidase C54 family. Expressed in a variety of tissues, including brain, skeletal muscle and fetal liver, Atg4a functions as a cysteine protease that cleaves the C~terminal part of target proteins, such as GABARAP and MAP1LC3, and plays an essential role in autophagy. Atg4a exists as multiple alternatively spliced isoforms and is functionally inhibited by N~ethylmaleimide.