Rabbit polyclonal antibody to Cleaved~Spectrin α II (D1185)

Fodrin (also named nonerythroid spectrin) is a universally expressed membrane~associated cytoskeletal protein consisting of alpha~ and beta~subunits. This protein is important for maintaining normal membrane structure and supporting cell surface protein function. Alpha~fodrin is one of the primary targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases to yield amino~terminal 150 kDa, carboxy~terminal 120 kDa and 35 kDa major products. Cleavage of alpha~fodrin leads to membrane malfunction and cell shrinkage.