Rabbit polyclonal antibody to Caspase 5 p20 (D121)

Caspase~5 (also designated ICErel~III, TY, ICH~3 and caspase~12 in mouse), can cleave its own precursor, an activity that requires the cysteine 245 residue. Frameshift mutations in caspase~5 have been identified in MMP tumors of the endometrium, colon, and stomach, indicating the caspase~5 may be a new target gene in the microsatellite mutator pathway for cancer. The human caspase 5 gene maps to chromosome 11q22.2~q22.3 and encodes a protein whose expression is barely detectable in most tissues except brain, with highest expression levels being found in lung, liver and skeletal muscle.