Rabbit polyclonal antibody to ALDOC

Fructose 1,6~bisphosphate aldolase catalyses the reversible condensation of glycerone~P and glyceraldehyde 3~phosphate into fructose 1,6~bisphosphate. Fructose 1,6~bisphosphate aldolase exists as three forms, the muscle~specific Aldolase A, the liver~specific aldolase B, and the brain~specific aldolase C. Aldolase A, B, and C arose from a common ancestral gene, from which aldolase B first diverged. Aldolase A is one of the most highly conserved enzymes known, with only about 2% of the residues changing per 100 million years. Aldolase B is regulated by the hormones insulin and glucagon and has been implicated in hereditary fructose intolerance disease. Aldolase C is a polypeptide that is exclusively expressed in Purkinje cells. Aldolase C~positive Purkinje cells are organized in the cerebellum as stripes or bands that run from anterior to posterior across the cerebellum and alternate with bands of Aldolase C~negative Purkinje cells.