Rabbit polyclonal antibody to CCP110

Centrosome duplication and separation are linked inextricably to certain cell cycle events, specifically, activation of cyclin~dependent kinases of cyclin~dependent kinases. CP110 (centrosomal protein of 110 kDa) is a 991 amino acid cell cycle~dependent CDK substrate that regulates centrosome duplication. Localizing to the centrosome, CP110 contains ten putative CDK2 phosphorylation sites, two cyclin~binding domains and two degradation motifs. CP110 is highly expressed in testis with much lower expression in all other tissues. CP110 interacts with Ca2+~binding proteins including calmodulin (CaM) and centrin, to regulate genome stability and progression through cytokinesis. During the formation of cylindrical centrioles, it is suggested that CP110 acts as a distal end~capping protein thereby limiting the elongation of newly formed centrioles. Existing as two alternatively spliced isoforms, CP110 is observed at highest levels during the S phase of the cell cycle. CP110 becomes phosphorylated by Cdks (cyclin~dependent kinases) and is encoded by a gene located on human chromosome 16p12.3.