Rabbit polyclonal antibody to IGLL1 (C194)

Lambda 5 (also called Immunoglobulin lambda~like polypeptide 1 or CD179b antigen) and VpreB comprise the surrogate light chain of the pre~B cell receptor complex. SL chain is also part of a quality control mechanism that tests a m~chain for its ability to pair with conventional L chains. It can form Ig~like complexes with the heavy (H) chain, the DHJHC m~protein or the p55 chain. Production of the surrogate light chain begins at the stage of pro~B cells, continues during the pre~B~cell stage and halts at the immature B cell stage. Once pre~BCR is expressed, SL chain expression is turned off. As pre~B II cells proliferate, SL is diluted out, thus limiting pre~BCR formation. Lambda 5 is critical for B cell development in mammals. Expression of Lambda 5 is highest in liver, pre~ B~lymphocytes and bone marrow, the major source of B cell precursors.