Rabbit polyclonal antibody to IL3RA

IL3RA/CD123 is the alpha subunit of an IL~3 receptor that also contains the common beta chain (βc) shared with receptors for other cytokines. IL3RA/CD123 alone binds to IL~3 with high specificity but low affinity and it does not transduce intracellular signaling, while βc alone does not bind to IL~3 appreciably. Together, IL3RA/CD123 and βc form the functional high~affinity receptor for IL~3. IL3RA/CD123 is mainly expressed on the hematopoietic progenitor cells, primarily the granulocytic and monocytic linages . IL3RA/CD123 is highly expressed on leukemic stem cells in the majority of AML (acute myeloid leukemia) patients and is correlated with poor prognosis. In addition, overexpression of IL3RA/CD123 has also been reported for other hematopoietic malignancies. It is considered as a valuable therapeutic target for these malignancies.