Rabbit polyclonal antibody to TREM1

TREM~1 (triggering receptor expressed on myeloid cells~1) is expressed in monocytes and neutrophils but not in lymphocytes, dendritic cells, or other cell types. TREM~1 is a glycoprotein that is reduced by deglycosylation, in agreement with the predicted molecular mass. TREM~1 is an activating receptor of the Ig superfamily that is expressed on human myeloid cells, selectively expressed on blood neutrophils and a subset of monocytes, and is upregulated by bacterial LPS. Immunoblot analysis shows that TREM~1 is associated with DAP12, a molecule frequently associated with activating receptors. TREM~1 and the myeloid DAP12~associating lectin (MDL~1) are recently identified receptors which associate non~covalently with DAP12 to form receptor complexes that are involved in monocytic activation and inflammatory response.