Rabbit polyclonal antibody to ICAM~5

Cell adhesion molecules are a family of closely related cell surface glycoproteins involved in cell~cell interactions during growth and are thought to playimportant, yet separate, roles in embryogenesis and development. The intracellular adhesion molecule~1 (ICAM~1), also referred to as CD54, is an integral membrane protein of the immunoglobulin superfamily and recognizes the β2α1 and β2αM integrins. ICAM~2 functions as a ligand for lymphocyte functionassociated antigen~1 (LFA~1) and is involved in leukocyte adhesion. ICAM~3 is highly expressed on the surface of human eosinophils, and when bound to ligand may inhibit eosinophil inflammatory responses and survival. ICAM~4, also known as LW glycoprotein, interacts with the integrins αLβ2, αMβ2, α4β1, the αV family and αIIbβ3, and selective binding to different integrins may be relevant to the pathology in a number of red blood cell associated diseases. Lastly, ICAM~5, expressed on telencephalic neurons, binds CD11a/CD18 and thus may act as an adhesion molecule for leukocyte binding in the central nervous system.