Rabbit polyclonal antibody to PP2A~α

PP2A is the major phosphatase for microtubule~associated proteins (MAPs).PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen~stimulated S6 kinase, and MAP~2 kinase.Cooperates with SGO2 to protect centromeric cohesin from separase~mediated cleavage in oocytes specifically during meiosis I (By similarity).Can dephosphorylate SV40 large T antigen and p53/TP53.Activates RAF1 by dephosphorylating it at 'Ser~259'.Mediates dephosphorylation of WEE1, preventing its ubiquitin~mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint.Mediates dephosphorylation of MYC; promoting its ubiquitin~mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC.Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3.