Rabbit polyclonal antibody to PLD2 (phospho~Y169)

Phosphatidylcholine phospholipase D1 and D2 (PC~PLD1 and PC~PLD2) are phospholipid~specific phosphodiesterases that hydrolyze phosphatidylcholine. Unlike PC~PLD1, which associates with secretory granules, PC~PLD2 localizes to the plasma membrane, where it is implicated in the formation of endocytotic vesicles. Both PC~PLD1 and PC~PLD2 coordinately regulate macrophage phagocytosis. PC~PLD activity in mammalian cells is transiently stimulated upon activation by G protein~coupled and receptor tyrosine kinase cell surface receptors. In addition, tubulin binding to PC~PLD2 inhibits muscarinic receptor~linked PC~PLD2 activation. PC~PLD2 also enhances PKCzeta activity through direct interaction in a lipase activity~independent manner.