Rabbit polyclonal antibody to Gab 1 (phospho~Y627)

Gab 1 (GRB2~associated binder 1), one such member of the IRS family, plays an important role in cellular growth response, transformation and apoptosis. Gab 1 is a multi~substrate docking protein that functions downstream in the signaling pathways of different receptor kinases, including EGFR. Gab1 is tyrosine phosphorylated normally in response to insulin and consequently enhances phosphatidylinositol 3~ kinase (PI3K) binding. In response to osmotic shock, tyrosine~phosphorylated Gab 1 (p~Gab 1) also binds and activates phosphatidylinositol 3~kinase, suggesting that Gab 1 is the major site for PI3K recruitment following osmotic shock stimulation.