Rabbit polyclonal antibody to Dok~2 (phospho~Y299)

Dok~1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that p62 Dok~1 is a substrate of the constitutive tyrosine kinase activity of p210 Bcr~Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok~1, as well as the tyrosine kinase substrates IRS~1 and Cas, is a member of a class of “docking” proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok~1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Dok~2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr~Abl.