Rabbit polyclonal antibody to CPI~17 (phospho~T38)

CPI~17 is a phosphorylation~dependent inhibitory protein for smooth muscle myosin phosphate. CPI~17 was originally identified as a PKC~potentiated inhibitory protein of protein phosphatase~1, which is dominantly expressed in smooth muscle. Phosphorylation at Threonine 38, in vitro, by PKC or Rho~kinase enhances the inhibitory potency toward myosin phosphatase. CPI~17 is also phosphorylated at Threonine 38 by protein kinase N and might be involved in the calcium sensitization of smooth muscle contraction as a downstream effector of Rho and/or arachidonic acid. CPI~17 is dually phosphorylated at Serine 12 and Threonine 38 by a MYPT~associated kinase, M110 kinase.