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Rabbit polyclonal antibody to 4E~BP1 (phospho~T46)

Western blot (WB) analysis of p~4E~BP1 (T46) pAb at 1:500 dilution Lane1:PC3 whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:SGC7901 whole cell lysate(40ug) Lane4:EC9706 whole cell lysate(40ug) Lane5:Panc1 whole cell lysate(40ug) Lane6:3T3~L1 whole cell lysate(40ug) Lane7:PC12 whole cell lysate(20ug)

Rabbit polyclonal antibody to 4E~BP1 (phospho~T46)

货号：
54139
别名：
Eukaryotic translation initiation factor 4E~binding protein 1; 4E~BP1; eIF4E~binding protein 1; Phosphorylated heat~ and acid~stable protein regulated by insulin 1; PHAS~I; EIF4EBP1; 4EBP1; PHAS I; PHASI;
产品上架时间：
2024-01-01
应用：
WB IHC IP
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q13541
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1180

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Rabbit polyclonal antibody to 4E~BP1 (phospho~T46)

Description
The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF~4F, which associates with the mRNA 5' cap structure. eIF~4E, a component of eIF~4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF~4F complex. The regulatory protein 4E~BP1, also referred to as PHAS~I, inhibits eIF~4E function. Phosphorylation of 4E~BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E~BP1 from eIF~4E, promoting translation. A protein that is functionally related to 4E~BP1, designated 4E~BP2, also associates with eIF~4E.

Description

The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF~4F, which associates with the mRNA 5' cap structure. eIF~4E, a component of eIF~4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF~4F complex. The regulatory protein 4E~BP1, also referred to as PHAS~I, inhibits eIF~4E function. Phosphorylation of 4E~BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E~BP1 from eIF~4E, promoting translation. A protein that is functionally related to 4E~BP1, designated 4E~BP2, also associates with eIF~4E.

Specification
Aliases	Eukaryotic translation initiation factor 4E~binding protein 1; 4E~BP1; eIF4E~binding protein 1; Phosphorylated heat~ and acid~stable protein regulated by insulin 1; PHAS~I; EIF4EBP1; 4EBP1; PHAS I; PHASI;
Swissprot	Q13541
clone	2B9F5
WB Predicted band size	~15to20kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic phosphopeptide derived from human 4E~BP1 around the phosphorylation site of Threonine 46.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2