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Rabbit polyclonal antibody to Cofilin (phospho~S3)

Western blot (WB) analysis of p~Cofilin (S3) pAb at 1:500 dilution Lane1:SGC7901 whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug)

Rabbit polyclonal antibody to Cofilin (phospho~S3)

货号：
54132
别名：
Cofilin~1; 18 kDa phosphoprotein; p18; Cofilin; non~muscle isoform; CFL1; CFL
产品上架时间：
2024-01-01
应用：
WB IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P23528
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1180

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Rabbit polyclonal antibody to Cofilin (phospho~S3)

Description
Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly, essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous F~Actin by bridging two longitudinally~associated Actin subunits, changing the F~Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors like opsonized zymosan. LIM kinase 1 (LIMK~1), a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerize F~Actin.

Description

Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly, essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous F~Actin by bridging two longitudinally~associated Actin subunits, changing the F~Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors like opsonized zymosan. LIM kinase 1 (LIMK~1), a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerize F~Actin.

Specification
Aliases	Cofilin~1; 18 kDa phosphoprotein; p18; Cofilin; non~muscle isoform; CFL1; CFL
Swissprot	P23528
clone	8G5D9
WB Predicted band size	~19kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic phosphopeptide derived from human Cofilin 1 around the phosphorylation site of Serine 3.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2