Rabbit polyclonal antibody to TPH1 (phospho~S260)

Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L~amino acids. PAH, TH and TPH all contain catalytic domains with an amino~terminal regulatory domain and a short carboxy~terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate and is likely to be involved in the formation of the hydroxylating intermediate. TPH is the first and rate~limiting step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland.