Rabbit polyclonal antibody to c~Fos (phospho~S362)

The c~Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c~Fos, encodes a nuclear phospho~protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c~Jun proteins, which form homo~ and heterodimers which bind to specific DNA response elements, c~Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c~Fos include the Fra~1, Fra~2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP~1 and CRE sites.