Rabbit polyclonal antibody to Catenin~δ1 (phospho~Y228)

Catenin δ~1 (p120 catenin) has an amino~terminal coiled~coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42~amino acid repeats. The carboxy~terminal tail has no known function. Catenin δ~1 fulfills critical roles in the regulation of cell~cell adhesion as it regulates E~cadherin turnover at the cell surface to determine the level of E~cadherin available for cell~cell adhesion. Catenin δ~1 has both positive and negative effects on cadherin~mediated adhesion. Actin dynamics are also regulated by catenin δ~1, which modulates RhoA, Rac, and cdc42 proteins. Analogous to β~catenin, catenin δ~1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ~1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin δ~1 may function as a tumor suppressor.