Rabbit polyclonal antibody to PKAα/β cat (phospho~T197)

PRKACA and PRKACB are members of the Ser/Thr protein kinase family and are a catalytic subunit of cAMP~dependent protein kinase. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP~dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.