Rabbit polyclonal antibody to Calnexin (phospho~S583)

Calnexin and Calregulin (also called Calreticulin) are calcium~binding proteins that are localized to the endoplasmic reticulum—Calnexin to the membrane and Calregulin to the lumen. Calnexin is a type I membrane protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may play a role in assisting with protein assembly and in retaining unassembled protein subunits in the endoplasmic reticulum. Calregulin has both low~ and high~affinity calcium~binding sites. Neither Calnexin nor Calregulin contains the calcium~binding “E~F hand” motif found in calmodulins. Calnexin and Calregulin are important for the maturation of glycoproteins in the endoplasmic reticulum and appear to bind many of the same proteins.