Rabbit polyclonal antibody to PLC γ2 (phospho~Y753)

Phosphoinositide~specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5~triphosphate and diacylglycerol from phosphatidylinositol 4,5~bisphosphate. There are many mammalian PLC isozymes, including PLC β1, PLC β2, PLC β3, PLC β4, PLCγ1, PLCγ2, PLC δ1, PLC δ2 and PLCe. PLCδ exists as four different isoforms. PLC δ1, a calcium signal amplifier, is activated by an atypical GTP~binding protein. In addition, PLC δ1 is an effector for GTP~binding protein transglutaminase II~mediated oxytocin receptor and α1B~adrenoreceptor signaling. Mouse PLC δ1 is highly expressed in brain, heart, lung and testis. PLC δ is abnormally accumulated in autopsied brains with Alzheimer’s disease (AD), suggesting that it may play a role in the pathology of AD. PLC δ2 is markedly expressed in type II intestinal metaplasia and in the adenocarcinoma. When PLC δ2 is expressed in type I intestinal metaplasia, the metaplasia is generally considered benignant, yet evolves toward neoplastic transformation. Thus, PLC δ2 expression may be a possible marker of gastric malignant transformation.