Rabbit polyclonal antibody to GRF~1 (phospho~Y1105)

GRF~1 (glucocorticoid receptor DNA~binding factor 1), also known as p190RhoGAP or simply p190, is a transcriptional regulator which binds to the promoter region of the glucocorticoid receptor gene and represses its expression. By repressing GR expression, GRF~1 acts to down~regulate Rho signaling, thereby mediating both actin cytoskeletal rearrangements and cell cycle events. Through its GAP domain, GRF~1 is thought to affect cytokinesis by regulating Rho activity; a regulation that is controlled by the ubiquination of the GTP binding region and subsequent degradation of GRF~1. Additionally, GRF~1 plays an important role in oligodendrocyte differentiation, a process that is absent in malignant glioma tumors, implicating GRF~1 as a possible tumor suppressor. GRF~1 expression is regulated by glucocorticoids and the expressed protein exists as two isoforms produced by alternative splicing events.