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Rabbit polyclonal antibody to RUNX1 (phospho~S249)

Western blot (WB) analysis of p~RUNX1 (S249) pAb at 1:500 dilution Lane1:3T3~L1 whole cell lysate(40ug) Lane2:The Thymus tissue lysate of Rat(40ug) Lane3:K562 whole cell lysate(40ug) Lane4:Myla2059 whole cell lysate(40ug)

Rabbit polyclonal antibody to RUNX1 (phospho~S249)

货号：
54043
别名：
Runt~related transcription factor 1; Acute myeloid leukemia 1 protein; Core~binding factor subunit alpha~2; CBF~alpha~2; Oncogene AML~1; Polyomavirus enhancer~binding protein 2 alpha B subunit; PEA2~alpha B; PEBP2~alpha B; SL3~3 enhancer factor 1 alpha B subunit; SL3/AKV core~binding factor alpha B subunit; RUNX1; AML1; CBFA2
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q01196
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to RUNX1 (phospho~S249)

Description
AML1 (also known as Runx1, CBFA2, and PEBP2αB) is a member of the core binding factor (CBF) family of transcription factors. It is required for normal development of all hematopoietic lineages. AML1 forms a heterodimeric DNA binding complex with its partner protein CBFβ and regulates the expression of cellular genes by binding to promoter and enhancer elements. AML1 is commonly translocated in hematopoietic cancers: chromosomal translocations include t(8;21) AML1~ETO, t(12;21) TEL~AML, and t(8;21) AML~M2. Phosphorylation of AML1 on several potential serine and threonine sites, including Ser249, is thought to occur in an Erk~dependent manner.

Description

AML1 (also known as Runx1, CBFA2, and PEBP2αB) is a member of the core binding factor (CBF) family of transcription factors. It is required for normal development of all hematopoietic lineages. AML1 forms a heterodimeric DNA binding complex with its partner protein CBFβ and regulates the expression of cellular genes by binding to promoter and enhancer elements. AML1 is commonly translocated in hematopoietic cancers: chromosomal translocations include t(8;21) AML1~ETO, t(12;21) TEL~AML, and t(8;21) AML~M2. Phosphorylation of AML1 on several potential serine and threonine sites, including Ser249, is thought to occur in an Erk~dependent manner.

Specification
Aliases	Runt~related transcription factor 1; Acute myeloid leukemia 1 protein; Core~binding factor subunit alpha~2; CBF~alpha~2; Oncogene AML~1; Polyomavirus enhancer~binding protein 2 alpha B subunit; PEA2~alpha B; PEBP2~alpha B; SL3~3 enhancer factor 1 alpha B subunit; SL3/AKV core~binding factor alpha B subunit; RUNX1; AML1; CBFA2
Swissprot	Q01196
clone	5A3G10
WB Predicted band size	~55kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic phosphopeptide derived from human RUNX1 around the phosphorylation site of Serine 249.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2