Rabbit polyclonal antibody to SRF (phospho~S103)

Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF~binding sites are also constitutive promotor elements in many muscle~specific promotors. At the c~Fos SRE, formation of a ternary complex containing SRF and its accessory protein p62TCF appears to be important for signal transduction. Two related Ets domain proteins, Elk~1 and SRF accessory protein~1 (SAP~1) have DNA binding properties identical to that of p62TCF. Elk~1 and SAP~1 contain two homologous regions of which the two amino~terminal regions, the Ets domain (box A) and the B box, mediate ternary complex formation with SRF.