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Rabbit polyclonal antibody to Rb (phospho~S795)

Western blot (WB) analysis of p~Rb (S795) pAb at 1:500 dilution Lane1:SGC7901 whole cell lysate(40ug) Lane2:SGC7901 treated with PBS (1×PBS,PH7.4) for 3 hours whole cell lysate(40ug)

Rabbit polyclonal antibody to Rb (phospho~S795)

货号：
54030
别名：
Retinoblastoma~associated protein; p105~Rb; pRb; Rb; pp110; RB1
产品上架时间：
2024-01-01
应用：
WB IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P06400
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to Rb (phospho~S795)

Description
The retinoblastoma tumor suppressor gene product, known as Rb or pRb, regulates differentiation, apoptosis and cell cycle control by coordinating the cell cycle, at G1/S, with transcriptional machinery that includes the heterodimeric E2F family. During G1, cyclin D (D1, 2, 3)~dependent kinase~mediated phosphorylation of Rb at Ser 795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues, including Ser 249/Thr 252, Thr 373, Thr 356, Ser 780, Ser 807/Ser 811 and Thr 821/Thr 826.

Description

The retinoblastoma tumor suppressor gene product, known as Rb or pRb, regulates differentiation, apoptosis and cell cycle control by coordinating the cell cycle, at G1/S, with transcriptional machinery that includes the heterodimeric E2F family. During G1, cyclin D (D1, 2, 3)~dependent kinase~mediated phosphorylation of Rb at Ser 795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues, including Ser 249/Thr 252, Thr 373, Thr 356, Ser 780, Ser 807/Ser 811 and Thr 821/Thr 826.

Specification
Aliases	Retinoblastoma~associated protein; p105~Rb; pRb; Rb; pp110; RB1
Swissprot	P06400
clone	10C3E10
WB Predicted band size	~106kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic phosphopeptide derived from human Rb around the phosphorylation site of Serine 795.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2