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Rabbit polyclonal antibody to PLC γ1 (phospho~Y783)

Western blot (WB) analysis of p~PLC γ1 (Y783) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:HEK293T treated with UV for 5 minutes then repair for 4 hours whole cell lysate(40ug) Lane3:HEK293T treated with UV for 5 minutes then repair for 6 hours whole cell lysate(40ug) Lane4:HEK293T treated with UV for 5 minutes then repair for 16 hours whole cell lysate(40ug) Lane5:HEK293T treated with UV for 5 minutes then repair for 24 hours whole cell lysate(40ug) Lane6:C6 whole cell lysate(40ug) Lane7:The Kidney tissue lysate of Mouse(40ug)

Rabbit polyclonal antibody to PLC γ1 (phospho~Y783)

货号：
54029
别名：
1~phosphatidylinositol 4,5~bisphosphate phosphodiesterase gamma~1; PLC~148; PLC148; Phosphoinositide phospholipase C~gamma~1; Phospholipase C~II; PLC~II; Phospholipase C2; PLC2I; Phospholipase C~gamma~1; PLC~gamma~1; PLCG1; PLC1; PLCγ1;
产品上架时间：
2024-01-01
应用：
WB IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P19174
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to PLC γ1 (phospho~Y783)

Description
Phosphoinositide~specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5~triphosphate and diacylglycerol from phosphatidylinositol 4,5~bisphosphate. There are many mammalian PLC isozymes, including PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1, PLC δ2 and PLC ε. PLC γ1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes and fibroblasts of the interstitial tissue. Actinregulatory protein Villin is tyrosine phosphorylated and associates with PLC γ1 in the brush border of intestinal epithelial cells. Villin regulates PLC γ1 activity by modifying its own ability to bind phosphatidylinositol 4,5~biphosphate. PLC γ1 binds α1β1 Integrin and modulates α1β1 Integrin~specific adhesion. PLC γ1 and Ca2+ play a direct role in VEGF~regulated endothelial growth, however this signaling pathway is not linked to FGF~mediated effects in primary endothelial cells.

Description

Phosphoinositide~specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5~triphosphate and diacylglycerol from phosphatidylinositol 4,5~bisphosphate. There are many mammalian PLC isozymes, including PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1, PLC δ2 and PLC ε. PLC γ1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes and fibroblasts of the interstitial tissue. Actinregulatory protein Villin is tyrosine phosphorylated and associates with PLC γ1 in the brush border of intestinal epithelial cells. Villin regulates PLC γ1 activity by modifying its own ability to bind phosphatidylinositol 4,5~biphosphate. PLC γ1 binds α1β1 Integrin and modulates α1β1 Integrin~specific adhesion. PLC γ1 and Ca2+ play a direct role in VEGF~regulated endothelial growth, however this signaling pathway is not linked to FGF~mediated effects in primary endothelial cells.

Specification
Aliases	1~phosphatidylinositol 4,5~bisphosphate phosphodiesterase gamma~1; PLC~148; PLC148; Phosphoinositide phospholipase C~gamma~1; Phospholipase C~II; PLC~II; Phospholipase C2; PLC2I; Phospholipase C~gamma~1; PLC~gamma~1; PLCG1; PLC1; PLCγ1;
Swissprot	P19174
clone	2A3D5
WB Predicted band size	~148kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic phosphopeptide derived from human PLC γ1 around the phosphorylation site of Tyrosine 783.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2