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Rabbit polyclonal antibody to eEF2K (phospho~S366)

Western blot (WB) analysis of p~eEF2K (S366) pAb at 1:1000 dilution Lane1:MCF~7 whole cell lysate(40ug) Lane2:Hela whole cell lysate(40ug) Lane3:A375 whole cell lysate(40ug)

Rabbit polyclonal antibody to eEF2K (phospho~S366)

货号：
54007
别名：
Elongation factor 2 kinase; eEF~2 kinase; eEF~2K; Calcium/calmodulin~dependent eukaryotic elongation factor 2 kinase; EEF2K
产品上架时间：
2024-01-01
应用：
WB IHC IP
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
O00418
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to eEF2K (phospho~S366)

Description
eEF2K is 105 kDa protein that is detected in skeletal muscle extracts and is phosphorylated rapidly by SAPK4, but poorly by p38, p38γ, JNK or ERK 2. SAPK4 phosphorylates eEF2K at Ser 359 and Ser 396 in vitro, causing its inactivation. The phosphorylation of eEF2K at Ser 359 is also induced by insulin~like growth factor~1. Ser 359 is in close proximity to Ser 366 and the Ser 366 residue also becomes phosphorylated in response to growth factors. eEF2K is phosphorylated by p70 S6 kinase at Ser 366 and this results in the inactivation of eEF2K, especially at low (micromolar) calcium concentrations.

Description

eEF2K is 105 kDa protein that is detected in skeletal muscle extracts and is phosphorylated rapidly by SAPK4, but poorly by p38, p38γ, JNK or ERK 2. SAPK4 phosphorylates eEF2K at Ser 359 and Ser 396 in vitro, causing its inactivation. The phosphorylation of eEF2K at Ser 359 is also induced by insulin~like growth factor~1. Ser 359 is in close proximity to Ser 366 and the Ser 366 residue also becomes phosphorylated in response to growth factors. eEF2K is phosphorylated by p70 S6 kinase at Ser 366 and this results in the inactivation of eEF2K, especially at low (micromolar) calcium concentrations.

Specification
Aliases	Elongation factor 2 kinase; eEF~2 kinase; eEF~2K; Calcium/calmodulin~dependent eukaryotic elongation factor 2 kinase; EEF2K
Swissprot	O00418
clone	1E9H10
WB Predicted band size	~105kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic phosphopeptide derived from human eEF2K around the phosphorylation site of Serine 366.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2