Rabbit polyclonal antibody to DARPP~32 (phospho~T75)

Dopaminergic signaling pathways, which are essential for multiple brain functions, are abnormal in several neurological disorders, such as schizophrenia, Parkinson’s disease and drug abuse. DARPP~32 (for dopamine and adenosine 3’,5’~monophosphate~regulated phosphoprotein of 32 kDa) is abundant in neurons that receive dopaminergic input. Activation of PKA and the consequent phosphorylation of DARPP~32 on threonine occurs in response to dopamine acting upon D1~like receptors. Dopamine interaction with D2~like receptors results in the inhibition of PKA activation, the activation of protein phosphatase 2B and the consequent dephosphorylation of DARPP~32. Neurotransmitters other than dopamine may also be able to stimulate the phosphorylation or dephosphorylation of DARPP~32. Phosphorylated DARPP~32 is a potent inhibitor of PP~1.