Rabbit polyclonal antibody to c~Jun (phospho~Y170)

The c~Jun proto~oncogene was first identified as the cellular homolog of the avian sarcoma virus v~Jun oncogene. The c~Jun protein, along with c~Fos, is a component of the AP~1 transcriptional complex. c~Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Homo~ and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Two additional genes, Jun B and Jun D, have been shown to be almost identical to c~Jun in their C~terminal regions, which are involved in dimerization and DNA binding, whereas their N~terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c~Fos and other members of the Fos gene family.