Rabbit polyclonal antibody to C/EBP~β (phospho~T235/188)

C/EBP β is a member of the C/EBP transcription factor family. The C/EBP β gene encodes several isoforms, which have truncated transcription activation domains by the alternative translational initiation at multipe AUG start sites. Initiation of translation at the in~frame AUGs forms four C/EBP β isoforms. C/EBP β is also known as interleukin 6~dependent DNA~binding protein (IL6DBP), liver activator protein(LAP) or liver~enriched transcriptional activator protein transcription factor 5 (TCF5). C/EBP β contributes to the regulation of the acute phase response in hepatocytes. Stat3 has an important function in IL~6~mediated transcription of the C/EBP β gene that has direct implication for acute phase response in liver cells.The 35 kDa C/EBP β form requires phosphorylation for its DNA binding ability, and increased binding of C/EBP β isoforms during acute~phase reaction occurs through its upregulation and structural modification.