Rabbit polyclonal antibody to CCN2

Connective tissue growth factor (CTGF, CCN2) belongs to the CCN (CYR61, CTGF, NOV) family of secreted extracellular matrix (ECM) proteins. Members of this family contain four conserved cysteine~rich domains, and interact in the ECM with a diverse array of cell surface receptors, including integrins and heparin~sulfate proteoglycans. These interactions regulate a multitude of cellular and tissue functions, including adhesion, proliferation, migration, differentiation, senescence, angiogenesis, inflammation, and wound repair. The CTGF gene is a transcriptional target of both YAP/TAZ and TGFβ~SMAD signaling pathways, and aberrant regulation of CTGF expression is strongly associated with pathological conditions, notably cancer and fibrosis.