Rabbit polyclonal antibody to LEF~1 (F38)

Transcription factor that binds DNA in a sequence~specific manner.Participates in the Wnt signaling pathway (By similarity).Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity).PIAG antagonizes both Wnt~dependent and Wnt~independent activation by LEF1 (By similarity).TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1.Regulates T~cell receptor alpha enhancer function.Required for IL17A expressing gamma~delta T~cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity).May play a role in hair cell differentiation and follicle morphogenesis (By similarity).