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Rabbit polyclonal antibody to PDK2 (R291)

Western blot (WB) analysis of PDK2 (R291) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:L02 whole cell lysate(40ug) Lane3:The brain tissue lysate of Mouse(40ug) Lane4:The brain tissue lysate of Rat(40ug) Lane5:The liver tissue lysate of Mouse(40ug) Lane6:The liver tissue lysate of Rat(40ug)

Rabbit polyclonal antibody to PDK2 (R291)

货号：
53979
别名：
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2; mitochondrial; PDHK2; PDK2; PDK2; Pyruvate dehydrogenase kinase isoform 2; Pyruvate dehydrogenase kinase; isozyme 2; Pyruvate dehydrogenase lipoamide kinase isozyme 2; mitochondrial
产品上架时间：
2024-01-01
应用：
WB IHC IP
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q15119
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to PDK2 (R291)

Description
The core of PDC is composed of sixty dihydrolypoyl acetyltransferase (E2) subunits that bind directly to PDK2 and enhance PDK2 kinase activity. Upregulation of PDK isoenzymes occurs during starvation conditions, rerouting acetyl~CoA generation by facilitating fatty acid oxidation. PDKs contain five conserved regions and are mechanistically similar to bacterial His~kinases, in that both require histidine residues for activity. In mammals, transcripts for PDK2 are ubiquitously expressed with high levels in heart and skeletal muscle and decreased levels in spleen and lung.

Description

The core of PDC is composed of sixty dihydrolypoyl acetyltransferase (E2) subunits that bind directly to PDK2 and enhance PDK2 kinase activity. Upregulation of PDK isoenzymes occurs during starvation conditions, rerouting acetyl~CoA generation by facilitating fatty acid oxidation. PDKs contain five conserved regions and are mechanistically similar to bacterial His~kinases, in that both require histidine residues for activity. In mammals, transcripts for PDK2 are ubiquitously expressed with high levels in heart and skeletal muscle and decreased levels in spleen and lung.

Specification
Aliases	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2; mitochondrial; PDHK2; PDK2; PDK2; Pyruvate dehydrogenase kinase isoform 2; Pyruvate dehydrogenase kinase; isozyme 2; Pyruvate dehydrogenase lipoamide kinase isozyme 2; mitochondrial
Swissprot	Q15119
clone	2F8E5
WB Predicted band size	~46kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 260~322 of Human PDK2.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2