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Rabbit polyclonal antibody to CEP290 (F812)

Western blot (WB) analysis of CEP290 (F812) polyclonal antibody at 1:500 dilution Lane1:HCT116 whole cell lysate(40ug) Lane2:SGC7901 whole cell lysate(40ug) Lane3:COS~7 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug) Lane5:CT26 whole cell lysate(40ug) Lane6:AML~12 whole cell lysate(40ug) Lane7:PC12 whole cell lysate(40ug)

Rabbit polyclonal antibody to CEP290 (F812)

货号：
53956
别名：
Centrosomal protein of 290 kDa; Cep290; Bardet~Biedl syndrome 14 protein; Cancer/testis antigen 87; CT87; Nephrocystin~6; Tumor antigen se2~2; CEP290; BBS14; KIAA0373; NPHP6
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
O15078
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to CEP290 (F812)

Description
CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. CEP290 is ubiquitously expressed; strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5), Senior~Loken syndrome type 6 (SLSN6), Leber congenital amaurosis type 10 (LCA10) and Meckel syndrome type 4 (MKS4). Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.

Description

CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. CEP290 is ubiquitously expressed; strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5), Senior~Loken syndrome type 6 (SLSN6), Leber congenital amaurosis type 10 (LCA10) and Meckel syndrome type 4 (MKS4). Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.

Specification
Aliases	Centrosomal protein of 290 kDa; Cep290; Bardet~Biedl syndrome 14 protein; Cancer/testis antigen 87; CT87; Nephrocystin~6; Tumor antigen se2~2; CEP290; BBS14; KIAA0373; NPHP6
Swissprot	O15078
clone	3A6B1
WB Predicted band size	~290kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 781~830 of Human CEP290.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2