Rabbit polyclonal antibody to IL~32 (K226)

Interleukin~32 (IL~32), also designated Natural Killer (NK) cell transcript 4 (nk4), may play a role in inflammatory responses such as lymphocyte activation. IL~32 is secreted following stimulation with inflammatory cytokines such as IL~1β and IFN~γ, and by NK cells after exposure to IL~12 and IL~18. It also induces production of IL~1β, TNFα, MIP~2 and IL~6. Expression of IL~32 increases after activation of T cells by mitogens or activation of NK cells by IL~2. The IL~32 protein contains three potential N~myristoylation sites, a tyrosine sulfation site, an RGD cellattachment sequence and multiple putative phosphorylation sites. Human IL~32 exists as four isoforms.