Rabbit polyclonal antibody to Cardiotrophin~1 (H31)

Cardiotrophin~1 (CT~1) is a member of the IL~6 family of cytokines, which signal through gp130 receptor complexes. gp130 complexes with several different receptor subunits to transmit signals from Cardiotrophin~1, IL~6, LIF, OSM, CNTF and IL~11. Cardiotrophin~1 binds to and activates the leukemia inhibitory factor (LIF) receptor/gp130 receptor complex and has been shown to induce hypertrophy in cardiac myocytes in vitro. Cardiotrophin~1, a secreted protein expressed at high levels in myocardium during cardiogenesis, has been shown to promote proliferation and survival of embryonic cardiomyocytes, suggesting a role for Cardiotrophin~1 in the activation of gp130 during cardiac development.