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Rabbit polyclonal antibody to Cofilin (M1)

Western blot (WB) analysis of Cofilin (M1) polyclonal antibody at 1:500 dilution Lane1:H9C2 whole cell lysate(40ug) Lane2:AML~12 whole cell lysate(40ug) Lane3:L02 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug) Lane5:MCF~7 whole cell lysate(40ug)

Rabbit polyclonal antibody to Cofilin (M1)

货号：
53898
别名：
Cofilin~1; 18 kDa phosphoprotein; p18; Cofilin; non~muscle isoform; CFL1; CFL
产品上架时间：
2024-01-01
应用：
WB IHC IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P23528
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to Cofilin (M1)

Description
Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly, essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous F~Actin by bridging two longitudinally~associated Actin subunits, changing the F~Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors like opsonized zymosan. LIM kinase 1 (LIMK~1), a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerize F~Actin.

Description

Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly, essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous F~Actin by bridging two longitudinally~associated Actin subunits, changing the F~Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors like opsonized zymosan. LIM kinase 1 (LIMK~1), a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerize F~Actin.

Specification
Aliases	Cofilin~1; 18 kDa phosphoprotein; p18; Cofilin; non~muscle isoform; CFL1; CFL
Swissprot	P23528
clone	7C4C6
WB Predicted band size	~19kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to the N~terminal of Human Cofilin 1.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2