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Rabbit polyclonal antibody to RUNX3 (R182)

Western blot (WB) analysis of RUNX3 (R182) pAb at 1:500 dilution Lane1:SGC7901 whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:AML~12 whole cell lysate(40ug) Lane4:H9C2 whole cell lysate(40ug)

Rabbit polyclonal antibody to RUNX3 (R182)

货号：
53886
别名：
Runt~related transcription factor 3; Acute myeloid leukemia 2 protein; Core~binding factor subunit alpha~3; CBF~alpha~3; Oncogene AML~2; Polyomavirus enhancer~binding protein 2 alpha C subunit; PEA2~alpha C; PEBP2~alpha C; SL3~3 enhancer factor 1 alpha C subunit; SL3/AKV core~binding factor alpha C subunit; RUNX3; AML2; CBFA3; PEBP2A3
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q13761
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1180

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Rabbit polyclonal antibody to RUNX3 (R182)

Description
RUNX family members are DNA~binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX3 is expressed in cells of hematopoietic origin, including myeloid and B~cell lines and spleen. By playing a role in controlling the growth and differentiation of gastric epithelial cells, RUNX3 is a strong candidate as a gastric cancer tumor suppressor. Specifically, hypermethylation inactivates the gene encoding RUNX3. The detection of hypermethylation at multiple regions within the RUNX3 CpG island may aid in the diagnosis and risk assessment of gastric cancer.

Description

RUNX family members are DNA~binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX3 is expressed in cells of hematopoietic origin, including myeloid and B~cell lines and spleen. By playing a role in controlling the growth and differentiation of gastric epithelial cells, RUNX3 is a strong candidate as a gastric cancer tumor suppressor. Specifically, hypermethylation inactivates the gene encoding RUNX3. The detection of hypermethylation at multiple regions within the RUNX3 CpG island may aid in the diagnosis and risk assessment of gastric cancer.

Specification
Aliases	Runt~related transcription factor 3; Acute myeloid leukemia 2 protein; Core~binding factor subunit alpha~3; CBF~alpha~3; Oncogene AML~2; Polyomavirus enhancer~binding protein 2 alpha C subunit; PEA2~alpha C; PEBP2~alpha C; SL3~3 enhancer factor 1 alpha C subunit; SL3/AKV core~binding factor alpha C subunit; RUNX3; AML2; CBFA3; PEBP2A3
Swissprot	Q13761
clone	3C8B2
WB Predicted band size	~48kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 150~201 of Human RUNX3.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2